Glucose transporter Glut1 controls diffuse invasion phenotype with perineuronal satellitosis in diffuse glioma microenvironment.
Masafumi MiyaiTomohiro KanayamaFuminori HyodoTakamasa KinoshitaTakuma IshiharaHideshi OkadaHiroki SuzukiShigeo TakashimaZhiliang WuYuichiro HatanoYusuke EgashiraYukiko EnomotoNoriyuki NakayamaAkio SoedaHirohito YanoAkihiro HirataMasayuki NiwaShigeyuki SugieTakashi MoriYoichi MaekawaToru IwamaMasayuki MatsuoAkira HaraHiroyuki TomitaPublished in: Neuro-oncology advances (2020)
Targeting the transporter Glut1 suppresses the unique phenotype, "diffuse invasion" in the diffuse glioma mouse model. This work leads to promising therapeutic and potential useful imaging targets for anti-invasion in human gliomas widely.