Severe Pneumococcal Pneumonia Causes Acute Cardiac Toxicity and Subsequent Cardiac Remodeling.
Luis Felipe ReyesMarcos I RestrepoCecilia A HinojosaNilam J SoniAntonio AnzuetoBettina L BabuNorberto Gonzalez-JuarbeAlejandro H RodriguezAlejandro JimenezJames D ChalmersStefano AlibertiOriol SibilaVicki T WinterJacqueline J CoalsonLuis D GiavedoniCharles S Dela CruzGrant W WatererMartin WitzenrathNorbert SuttorpPeter H DubeCarlos J OrihuelaPublished in: American journal of respiratory and critical care medicine (2017)
S. pneumoniae invades the myocardium and induces cardiac injury with necroptosis and apoptosis, followed by cardiac scarring after antibiotic therapy, in an NHP model of severe pneumonia.