Circulating microRNAs as minimal residual disease biomarkers in childhood acute lymphoblastic leukemia.
Andrea RzepielNóra KutszegiAndrás GézsiJudit C SágiBálint EgyedGyörgy PéterHenriett ButzGábor NyírőJudit MüllerGábor T KovácsCsaba SzalaiÁgnes F SemseiDániel J ErdélyiPublished in: Journal of translational medicine (2019)
In conclusion, these circulating miRs might act as biomarkers of residual leukemia. MiR-128-3p and miR-222-3p in blood predict day 15 flow cytometry MRD results 7 days earlier. Although, their sensitivity falls behind that of bone marrow flow cytometry MRD at day 15.