Molecular characterization of ESR1 variants in breast cancer.
Arielle L HeekeAndrew ElliottRebecca FeldmanHazel F O'ConnorPaula R PohlmannFilipa LynceSandra M SwainMaria R NunesDaniel MageeMatthew J OberleyJeffrey SwensonGregory VidalClaudine IsaacsLee SchwartzbergW Michael KornAntoinette R TanPublished in: Breast cancer research and treatment (2022)
We have described one of the largest series of ESR1 fusions reported. ESR1 LBD mutations were commonly identified in ER-positive disease. Limited data exists regarding the clinical impact of ESR1 fusions, which could be an area for future therapeutic exploration.