Effects of Hydroxysafflor Yellow A on the PI3K/AKT Pathway and Apoptosis of Pancreatic β-Cells in Type 2 Diabetes Mellitus Rats.

Maosheng LeeHuilin LiHengxia ZhaoMiao Suo Deliang Liu

Published in: Diabetes, metabolic syndrome and obesity : targets and therapy (2020)

The results of this study suggested that HSYA could promote PI3K/Akt activation and inhibit the apoptosis of pancreatic β-cells directly or indirectly, which might be the underlying mechanisms in HSYA to improve insulin resistance and regulate glycolipid metabolism in T2DM rats.

Keyphrases

cell cycle arrest
pi k akt
cell death
signaling pathway
induced apoptosis
insulin resistance
cell proliferation
endoplasmic reticulum stress
oxidative stress
adipose tissue
high fat diet