Low-dose Synachten test with measurement of salivary cortisol in adult patients with β-thalassemia major.

Alberto G AmbrogioLeila DanesiMarina BaldiniRaffaella RadinElena CassinerioGiovanna GraziadeiNadia MirraEmanuela D'AngeloAlessia MarconMarta MancarellaAlessandra OrsattiFederico BonettiMassimo ScacchiMaria Domenica CappelliniLuca PersaniFrancesca Pecori Giraldi

Published in: Endocrine (2018)

Our results attest to the need for testing for adrenal insufficiency among adult thalassaemic patients, as up to 20% presented impaired adrenal reserve. Salivary and serum cortisol levels during stimulation with ACTH were closely correlated and the use of salivary cortisol sampling during ACTH testing may represent a surrogate to serum cortisol in these patients.

Keyphrases

end stage renal disease
low dose
ejection fraction
chronic kidney disease
prognostic factors
peritoneal dialysis
high dose
young adults