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Lung tissue gene-expression signature for the ageing lung in COPD.

Maaike de VriesAlen FaizRoy R WoldhuisDirkje S PostmaTristan V de JongDon D SinYohan BosséDavid C NickleVictor GuryevHidde J HaismaMaarten van den BergeCorry-Anke Brandsma
Published in: Thorax (2017)
Our study indicates that processes related to lung development, cell-cell contacts, calcium signalling and immune responses are involved in lung ageing in general. Pathways related to extracellular matrix, mammalian target of rapamycin signalling, splicing of introns and exons and the ribosome complex are proposed to be involved in abnormal lung ageing in COPD.
Keyphrases
  • gene expression
  • extracellular matrix
  • immune response
  • chronic obstructive pulmonary disease
  • single cell
  • dna methylation
  • cell therapy
  • lung function
  • dendritic cells