Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington's Disease.

Ened Rodríguez-UrgellésDiana Casas-TorremochaAnna Sancho-BalsellsIván BallaschEsther García-GarcíaLluis Miquel-RioArnau ManasanchIgnacio Del CastilloWanqi ChenAnika PupakVeronica BritoDaniel TorneroManuel J RodríguezAnalia BortolozziMaria V Sanchez-VivesAlbert GiraltJordi Alberch

Published in: Cellular and molecular life sciences : CMLS (2023)

In conclusion, we show that a novel identified thalamic Foxp2 dysregulation alters basal ganglia circuits implicated in the pathophysiology of HD.

Keyphrases

regulatory t cells
deep brain stimulation
dendritic cells
resting state
white matter
functional connectivity