Early detection of radiation-induced lung damage with X-ray dark-field radiography in mice.

Rico BurkhardtThomas GoraAlexander A FingerleAndreas P SauterFelix MeurerStephan UmkehrerMaximilian von TeuffenbachSeverin KampferDaniela SchillingAnnette FeuchtingerAxel K WalchErnst RummenyStephanie E CombsThomas E SchmidFranz PfeifferJan J WilkensJulia Herzen

Published in: European radiology (2020)

• Significant deviations from healthy lung due to irradiation were measured after 16 weeks with x-ray dark-field radiography (p = 0.004). • Significant deviations occur on average 10 weeks earlier for x-ray dark-field radiography in comparison to x-ray transmission radiography. • Sensitivity and specificity doubled when using x-ray dark-field radiography instead of x-ray transmission radiography.

Keyphrases

dual energy
image quality
high resolution
radiation induced
cone beam computed tomography
computed tomography
electron microscopy
radiation therapy
oxidative stress
mass spectrometry
metabolic syndrome
adipose tissue