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Genetic deletion of dopamine D1 receptors increases the sensitivity to cannabinoid CB1 receptor antagonist-precipitated withdrawal when compared with wild-type littermates: studies in female mice repeatedly exposed to the Spice cannabinoid HU-210.

Antonia SerranoEvelyn VadasBelen FerrerAinhoa BilbaoNoelia GranadoJuan SuárezFrancisco Javier PavonRosario MoratallaFernando Rodríguez de Fonseca
Published in: Psychopharmacology (2021)
These results support for a role of dopamine D1 receptors in the acute, chronic, and withdrawal actions of spice drugs.
Keyphrases
  • wild type
  • drug induced
  • liver failure
  • respiratory failure
  • genome wide
  • case control
  • type diabetes
  • high fat diet induced
  • intensive care unit
  • hepatitis b virus
  • dna methylation