Cardiovascular disease risk factor responses to a type 2 diabetes care model including nutritional ketosis induced by sustained carbohydrate restriction at 1 year: an open label, non-randomized, controlled study.
Nasir H BhanpuriSarah J HallbergPaul T WilliamsAmy L McKenzieKevin D BallardWayne W CampbellJames P McCarterStephen D PhinneyJeff S VolekPublished in: Cardiovascular diabetology (2018)
A continuous care treatment including nutritional ketosis in patients with T2D improved most biomarkers of CVD risk after 1 year. The increase in LDL-cholesterol appeared limited to the large LDL subfraction. LDL particle size increased, total LDL-P and ApoB were unchanged, and inflammation and blood pressure decreased. Trial registration Clinicaltrials.gov: NCT02519309. Registered 10 August 2015.
Keyphrases
- low density lipoprotein
- cardiovascular disease
- type diabetes
- blood pressure
- healthcare
- phase iii
- palliative care
- quality improvement
- phase ii
- risk factors
- oxidative stress
- open label
- clinical trial
- study protocol
- double blind
- pain management
- affordable care act
- glycemic control
- placebo controlled
- insulin resistance
- adipose tissue
- skeletal muscle
- cardiovascular events