Local synovial engagement of angiogenic TIE-2 is associated with the development of persistent erosive rheumatoid arthritis in patients with early arthritis.
Marleen G H van de SandeDaphne de LaunayMaria J H de HairSamuel GarcíaGijs P M van de SandeCarla A WijbrandtsDanielle M GerlagKris A ReedquistPaul P TakPublished in: Arthritis and rheumatism (2014)
Local engagement of synovial TIE-2 is observed during the earliest phases of RA, suggesting that TIE-2 signaling may contribute to disease development and progression or may indicate an attempt to protect against these processes. Early therapeutic targeting of TIE-2 signaling may be useful in improving outcome in arthritis.