Effect of cellular and extracellular pathology assessed by T1 mapping on regional contractile function in hypertrophic cardiomyopathy.
Peter P SwobodaAdam K McDiarmidBara ErhayiemGraham R LawPankaj GargDavid A BroadbentDavid P RipleyTarique A MusaLaura E DobsonJames R FoleyGraham J FentStephen P PageJohn P GreenwoodSven PleinPublished in: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance (2017)
Impairment of contractile function in HCM is predominantly associated with the degree of hypertrophy and native T1 but not markers of extracellular fibrosis (ECV or LGE). These findings suggest that impairment of contractility in HCM is mediated by mechanisms other than extracellular expansion that include cellular changes in structure and function. The cellular mechanisms leading to increased native T1 and its prognostic significance remain to be established.