Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis.

Carolina de O Mendes-AguiarCamilla Lopes-SiqueiraFabrício Pettito-Assis Márcia Pereira-OliveiraManoel Paes de Oliveira-NetoClaude Pirmez Alda Maria Da Cruz Hiro Goto

Published in: Journal of immunology research (2021)

It is the first time that IGF-I was detected in lesions of infectious cutaneous disease, specifically in American tegumentary leishmaniasis. IGF-I was related to chronicity and good response to treatment. We may relate this finding to the efficient anti-inflammatory response and the known action of IGF-I in wound repair. The present data highlight the importance of searching nonspecific factors besides adaptive immune elements in the study of leishmaniasis' pathogenesis.

Keyphrases

growth hormone
inflammatory response
pi k akt
binding protein
signaling pathway
electronic health record
big data
cell proliferation
machine learning
immune response
wound healing
drug induced