The application of HER2 and CD47 CAR-macrophage in ovarian cancer.
Yizhao ChenXiangling ZhuHanze LiuCunzhi WangYu ChenHuihui WangYilong FangXuming WuYuting XuChunhua LiXinyue LvJinghua HuangXintong HanRuilin LiWenming HongZhiying YuWei WeiJiajie TuPublished in: Journal of translational medicine (2023)
We demonstrated the inhibition effect of our constructed novel HER2 CAR-M and CD47 CAR-M on target antigen-positive ovarian cancer in vitro and in vivo, and preliminarily verified that this inhibitory effect is due to phagocytosis, promotion of adaptive immunity and effect on tumor microenvironment.
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