Neurovascular unit disruption and blood-brain barrier leakage in MCT8 deficiency.
Marina Guillén-YuntaVíctor Valcárcel-HernándezÁngel García-AldeaGuadalupe SoriaJosé Manuel García-VerdugoAna Montero-PedrazuelaAna Guadaño-FerrazPublished in: Fluids and barriers of the CNS (2023)
These findings identify for the first time neurovascular alterations in the MCT8-deficient brain, including a disruption of the integrity of the BBB and alterations in the neurovascular unit ultrastructure as a new pathophysiological mechanism for AHDS. These results open a new field for potential therapeutic targets for the neurological symptoms of these patients and unveils magnetic resonance angiography as a new non-invasive in vivo technique for evaluating the progression of the disease.
Keyphrases
- blood brain barrier
- magnetic resonance
- cerebral ischemia
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- computed tomography
- optical coherence tomography
- minimally invasive
- peritoneal dialysis
- prognostic factors
- magnetic resonance imaging
- patient reported outcomes
- multiple sclerosis
- smoking cessation