Dose- and time-dependent effects of hyaluronidase on structural cells and the extracellular matrix of the skin.

Bettina Alexandra BuhrenHolger SchrumpfKatharina GorgesOliver ReinersEdwin BoelkeJens W FischerBernhard HomeyPeter Arne Gerber

Published in: European journal of medical research (2020)

HYAL is a bioactive enzyme that exerts multiple effects on the HA-metabolism as well as on the structural cells of the skin. Our results indicate that HYAL promotes wound healing and exerts a dose-dependent induction of HA-synthesis in structural cells of the skin. Herein, interestingly the most significant induction of HAS and HA were observed for the lowest concentration of HYAL.

Keyphrases

induced apoptosis
wound healing
extracellular matrix
cell cycle arrest
soft tissue
endoplasmic reticulum stress
signaling pathway
cell proliferation
recombinant human