Attenuation of COX-2 enzyme by modulating H 2 O 2 -mediated NF-κB signaling pathway by monoamine oxidase inhibitor (MAOI): a further study on the reprofiling of MAOI in acute inflammation.
Debjeet SurChaitali MondalAshok Kumar BalaramanPallab Kanti HaldarHimangshu Sekhar MajiAsis BalaPublished in: Inflammopharmacology (2023)
-mediated NF-κB-COX-2 pathway. The present investigation identifies MAOI might reprofile for the treatment of acute inflammation also, the MAO enzyme may use as a novel therapeutic target to design and develop new class of anti-inflammatory agents.
Keyphrases
- signaling pathway
- oxidative stress
- pi k akt
- liver failure
- respiratory failure
- anti inflammatory
- epithelial mesenchymal transition
- induced apoptosis
- aortic dissection
- drug induced
- lps induced
- genome wide
- hepatitis b virus
- immune response
- extracorporeal membrane oxygenation
- endoplasmic reticulum stress
- mechanical ventilation
- toll like receptor