Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis.

S BeltranM NassifE VicencioJ ArcosL LabradorB I CortesC CortezC A BergmannS EspinozaM F HernandezJ M MatamalaL BargstedS MatusD Rojas-RiveraM J M BertrandD B MedinasC HetzP A ManqueUte Woehlbier

Published in: Molecular neurodegeneration (2019)

This study, therefore, identifies Pacer as a new regulator of proteostasis associated with ALS pathology.

Keyphrases

genome wide
amyotrophic lateral sclerosis
cell death
endoplasmic reticulum stress
oxidative stress
signaling pathway
transcription factor
gene expression
protein protein
amino acid
binding protein