T helper cells expressing fractalkine receptor and bearing T follicular helper 1-like cell functions in patients with IgG4-related disease.

Yoshino InoueShingo NakayamadaSatoshi KuboKaoru YamagataKoshiro Sonomoto Shigeru IwataYusuke MiyazakiYoshiya Tanaka

Published in: Rheumatology (Oxford, England) (2022)

CX3CR1+ CD4+ T cells characteristically increased in the peripheral blood and the affected tissues and were associated with an increase in the serum IgG4 levels of patients with IgG4-RD. This CD4 subset has a Th1/Tfh-like phenotype and a B cell helper function.

Keyphrases

regulatory t cells
peripheral blood
dendritic cells
induced apoptosis
cell cycle arrest
gene expression
cell therapy
oxidative stress
mesenchymal stem cells
bone marrow
cell proliferation