WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis.

Panpan TaiXinyu ChenGuihua JiaGuanjun ChenLian GongYaxin ChengZhuan LiHeng WangAiyan ChenGanghua ZhangYuxing ZhuMengqing XiaoZhanwang WangYunqing LiuDongyong ShanDong HeMoying LiTianzuo ZhanAbbas KhanXiaohui LiXiangxiang ZengChaopeng LiDongsheng OuyangKelong AiXuan ChenDongbo LiuZhonghua LiuDongqing WeiKe Cao

Published in: Journal of translational medicine (2023)

Taken together, WGX50 protects DOX-induced cardiotoxicity via mitochondrial ROS and the ferroptosis pathway, which provides novel insights for WGX50 as a promising drug candidate for cardioprotection.

Keyphrases

cell death
oxidative stress
diabetic rats
high glucose
dna damage
drug induced
reactive oxygen species
drug delivery
emergency department
endothelial cells
radiation therapy
cancer therapy
stress induced