Enoxaparin does not ameliorate liver fibrosis or portal hypertension in rats with advanced cirrhosis.
José I ForteaAlexander ZipprichCarolina Fernandez-MenaMarta PuertoCristina R BosoiJorge AlmagroMarcus HollenbachJuan BañaresBelén Rodríguez-SánchezEmilia CercenadoMarc-André ClémentChristopher F RoseRafael BañaresJavier VaqueroCristina RipollPublished in: Liver international : official journal of the International Association for the Study of the Liver (2017)
Our results do not support a role of enoxaparin for improving liver fibrosis, portal hypertension or endothelial dysfunction in active disease at advanced stages of cirrhosis. These disease-related factors and the possibility of a limited therapeutic window should be considered in future studies evaluating the use of anticoagulants in cirrhosis.