Distribution and Temporal Dynamics of Plasmodium falciparum Chloroquine Resistance Transporter Mutations Associated With Piperaquine Resistance in Northern Cambodia.
Biraj ShresthaZalak ShahAndrew P MorganPiyaporn SaingamChaiyaporn ChaisatitSuwanna ChaorattanakaweeChantida PraditpolNonlawat BoonyalaiPaphavee LertsethtakarnMariusz WojnarskiMolly Deutsch-FeldmanMatthew AdamsDarapiseth SeaSoklyda ChannStuart D TynerCharlotte A LanteriMichele D SpringDavid L SaundersPhilip L SmithChanthap LonPanita GosiSomethy SokProm SatharathHuy RekolDysoley LekBrian A VeselyJessica T LinNorman C WatersShannon Takala-HarrisonPublished in: The Journal of infectious diseases (2022)
The large proportion of PfCRT mutants that lack pfpm2 amplification emphasizes the importance of including PfCRT mutations as part of molecular surveillance for piperaquine resistance in this region. Likewise, it is critical to monitor for amplified pfmdr1 in these PfCRT mutants, as increased mefloquine pressure could lead to mutants resistant to both drugs.