JMJD3 Promotes Myeloid Fibroblast Activation and Macrophage Polarization in Kidney Fibrosis.

Changlong AnBaihai JiaoHao DuMelanie TranBo SongPenghua WangDong ZhouYanlin Wang

Published in: British journal of pharmacology (2023)

Our study identifies JMJD3 as a critical regulator of myeloid fibroblast activation, macrophage polarization, and renal fibrosis development. Therefore, JMJD3 may represent a promising therapeutic target for chronic kidney disease.

Keyphrases

chronic kidney disease
dendritic cells
bone marrow
acute myeloid leukemia
end stage renal disease
transcription factor
liver fibrosis