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Comparative Genomics of Serial Candida glabrata Isolates and the Rapid Acquisition of Echinocandin Resistance during Therapy.

Amelia E BarberMichael WeberKerstin KaergerJörg LindeHanna GölzDaniel DuerschmiedAntonie MarkertReinhard GuthkeGrit WaltherOliver Kurzai
Published in: Antimicrobial agents and chemotherapy (2019)
The opportunistic pathogen Candida glabrata shows a concerning increase in drug resistance. Here, we present the analysis of two serial bloodstream isolates, obtained 12 days apart. Both isolates show pan-azole resistance and echinocandin resistance was acquired during the sampling interval. Genome sequencing identified nine nonsynonymous SNVs between the strains, including a S663P substitution in FKS2 and previously undescribed SNVs in MDE1 and FPR1, offering insight into how C. glabrata acquires drug resistance and adapts to a human host.
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