The ATG16L1 gene variant rs2241880 (p.T300A) is associated with susceptibility to HCC in patients with cirrhosis.

Philipp Alexander ReukenPhilipp LutzMarkus CasperEihab Al-HerwiSven StengelUlrich SpenglerAndreas StallmachFrank LammertHans Dieter NischalkeKaren Schmidt

Published in: Liver international : official journal of the International Association for the Study of the Liver (2019)

The common germ-line ATG16L1 gene variant is a risk factor for HCC in patients with cirrhosis. Personalized strategies employing the genetic risk conferred by ATG16L1 and PNPLA3 may be used for risk-based surveillance in cirrhosis.

Keyphrases

genome wide
copy number
public health
gene expression
dna methylation
genome wide identification
breast cancer risk