Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats.

Ibrahim Ethem Torun Yasemin Baranoglu Kılınc Erkan Kilinc

Published in: Arquivos de neuro-psiquiatria (2022)

Our findings suggest that endogenous and exogenous serotonin exhibits anticonvulsant effects by suppressing the neuroinflammation. It seems that 5-HT1B/D receptors do not mediate anticonvulsant and anti-neuroinflammatory effects of serotonin.

Keyphrases

traumatic brain injury
lipopolysaccharide induced
lps induced
cognitive impairment
high glucose
cerebral ischemia
diabetic rats
drug induced
oxidative stress
subarachnoid hemorrhage