Activation of Autoreactive Lymphocytes in the Lung by STING Gain-of-function Mutation Radioresistant Cells.

Kevin MingJie GaoKerstin NündelKristy ChiangXihui YinPaul J UtzKatherine A Fitzgerald Ann Marshak-Rothstein

Published in: bioRxiv : the preprint server for biology (2023)

Chimeric mice expressing STING only in non-hematopoietic cells develop systemic and lung directed autoimmunity which recapitulates what is seen in pediatric patients with SAVI disease.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
bone marrow
signaling pathway
cell death
cell therapy
adipose tissue
young adults