Effects of Latency on Estimates of the COVID-19 Replication Number.

There is continued uncertainty in how long it takes a person infected by the COVID-19 virus to become infectious. In this paper, we quantify how this uncertainty affects estimates of the basic replication number [Formula: see text], and thus estimates of the fraction of the population that would become infected in the absence of effective interventions. The analysis is general, and applies to all SEIR-based models, not only those associated with COVID-19. We find that when modeling a rapidly spreading epidemic, seemingly minor differences in how latency is treated can lead to vastly different estimates of [Formula: see text]. We also derive a simple formula relating the replication number to the fraction of the population that is eventually infected. This formula is robust and applies to all compartmental models whose parameters do not depend on time.