Association of long-term hyperglycaemia and insulin resistance with brain atrophy and cognitive decline: A longitudinal cohort study.
Ji Hee YuRegina E Y KimSo Young ParkDa Young LeeHyun Joo ChoNam Hoon KimHye Jin YooJi A SeoSin Gon KimKyung Mook ChoiSei Hyun BaikChol ShinNan Hee KimPublished in: Diabetes, obesity & metabolism (2022)
Long-term hyperglycaemia was a major independent factor associated with rapid cognitive decline in middle-aged adults with diabetes. Maintaining ideal glucose levels in diabetes at midlife might prevent later rapid cognitive decline.
Keyphrases
- cognitive decline
- mild cognitive impairment
- type diabetes
- insulin resistance
- middle aged
- glycemic control
- cardiovascular disease
- blood glucose
- metabolic syndrome
- white matter
- resting state
- high fat diet
- skeletal muscle
- multiple sclerosis
- functional connectivity
- blood brain barrier
- weight loss
- brain injury
- quantum dots