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Opioid analgesic dose and the risk of misuse, overdose, and death: A narrative review.

David Tyler CoyleChih-Ying PrattJosephine Ocran-AppiahAlex SecoraCynthia KornegayJudy Staffa
Published in: Pharmacoepidemiology and drug safety (2017)
The reviewed studies show an increasing risk of serious adverse health outcomes-including misuse, overdose, and death-associated with increasing opioid analgesic dose. Further research is needed to characterize the relationship between opioid analgesic dose and the risk of addiction and abuse. This analysis could inform policy actions for regulators and clinical decision making for providers.
Keyphrases
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