Longitudinal multi-omic changes in the transcriptome and proteome of peripheral blood cells after a 4 Gy total body radiation dose to Rhesus macaques.

Shanaz A GhandhiShad R MortonIgor ShuryakYounghyun LeeRajesh K SoniJay R PerrierJames BakkeJanet GahaganKim BujoldSimon AuthierSally A AmundsonDavid J BrennerDenise NishitaPolly ChangHelen C Turner

Published in: BMC genomics (2023)

Overall, we show that the TBI 4 Gy dose in NHPs induces many cellular changes that persist up to 1 month after exposure, consistent with damage, death, and repopulation of blood cells.

Keyphrases

induced apoptosis
peripheral blood
cell cycle arrest
traumatic brain injury
oxidative stress
gene expression
endoplasmic reticulum stress
cell death
genome wide
single cell