Interdependent Conductances Drive Infraslow Intrinsic Rhythmogenesis in a Subset of Accessory Olfactory Bulb Projection Neurons.
Monika GorinChryssanthi TsitouraAnat KahanKatja WatznauerDaniela R DroseMartijn ArtsRudolf MatharSimon O'ConnorIleana L Hanganu-OpatzYoram Ben-ShaulMarc SpehrPublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2016)
We show for the first time that some rodent accessory olfactory bulb mitral cells-the direct link between vomeronasal sensory input and limbic output-are intrinsically rhythmogenic. Driven by ≥ 3 distinct interdependent ionic conductances, infraslow intrinsic oscillations show remarkable periodicity both in vitro and in vivo. As a novel default state, infraslow autorhythmicity is likely to affect limbic processing of pheromonal information.
Keyphrases
- induced apoptosis
- cell cycle arrest
- mitral valve
- spinal cord
- functional connectivity
- left ventricular
- working memory
- left atrial
- cell death
- resting state
- endoplasmic reticulum stress
- health information
- magnetic resonance imaging
- heart failure
- oxidative stress
- aortic stenosis
- image quality
- transcatheter aortic valve replacement
- contrast enhanced