LGI1 Autoantibodies Enhance Synaptic Transmission by Presynaptic K v 1 Loss and Increased Action Potential Broadening.
Andreas Ritzau-JostFelix GsellJosefine SellStefan SachsJacqueline MontanaroToni KirmannSebastian MaaßSarosh R IraniChristian WernerChristian GeisMarkus SauerRyuichi ShigemotoStefan HallermannPublished in: Neurology(R) neuroimmunology & neuroinflammation (2024)
1.2 on presynaptic boutons, without actions on calcium channel density or function, thereby broadening the presynaptic action potential and increasing neurotransmitter release. This study provides a molecular explanation for the neuronal hyperactivity observed in patients with LGI1 autoantibodies.