Significant Association of Polymorphisms in the TCF7L2 Gene with a Higher Risk of Type 2 Diabetes in a Moroccan Population.

Sarah ElhourchHousna ArrouchiNour MekkaouiYounes AllouFatima GhrifiLoubna AllamNaima ElhafidiLahcen BelyamaniAzeddine IbrahimiNaoual ElomriRachid Eljaoudi

Published in: Journal of personalized medicine (2021)

The present study confirmed a significant association of the TCF7L2 gene (rs7903146 (C/T) and rs12255372 (G/T) polymorphisms with a higher risk to T2DM in the Moroccan population. No significant difference in respect to anthropometric and metabolic parameters between different genotypes.

Keyphrases

copy number
body composition
genome wide identification
type diabetes
gene expression
skeletal muscle
dna methylation
transcription factor
insulin resistance