Effects of B-cell directed therapy on the preclinical stage of rheumatoid arthritis: the PRAIRI study.

Danielle M GerlagMary SafyKaren I MaijerMan Wai TangSander W TasMirian J F Starmans-KoolAstrid van TubergenMatthijs JanssenMaria de HairMonika HanssonNiek de VriesAeilko H ZwindermanPaul P Tak

Published in: Annals of the rheumatic diseases (2018)

A single infusion of 1000 mg rituximab significantly delays the development of arthritis in subjects at risk of developing RA, providing evidence for the pathogenetic role of B cells in the earliest, prearthritis stage of autoantibody positive RA.

Keyphrases

rheumatoid arthritis
disease activity
ankylosing spondylitis
interstitial lung disease
diffuse large b cell lymphoma
low dose
cell therapy
systemic lupus erythematosus
bone marrow
idiopathic pulmonary fibrosis
chemotherapy induced