Evaluation of the influence of genetic variants in Cereblon gene on the response to the treatment of erythema nodosum leprosum with thalidomide.

Perpétua do Socorro Silva CostaMiriãn Ferrão Maciel-FiuzaThayne Woycinck KowalskiLucas Rosa FragaMariléa Furtado FeiraLuís Marcelo Aranha CamargoDaniele Iop de Oliveira CaldoncelliMaria Irismar da Silva SilveiraLavínia Schuler-FacciniFernanda Sales Luiz Vianna

Published in: Memorias do Instituto Oswaldo Cruz (2022)

Our results show that CRBN variants affect the treatment of ENH with thalidomide, especially on the adverse effects related to the drug.

Keyphrases

copy number
emergency department
genome wide
transcription factor
drug induced