The Effect of Single Dose Methylphenidate on Neurometabolites according to COMT Gene Val158Met Polymorphism in the Patient with Attention Deficit Hyperactivity Disorder: A Study Using Magnetic Resonance Spectroscopy.
Onder OzturkHuseyin AlacamBurge Kabukcu BasayOmer BasayAhmet BuberOzlem Izci AyKadir AgladıogluMehmet Emin ErdalHasan HerkenPublished in: Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology (2016)
These findings suggest that polymorphisms of the COMT gene can account for individual differences in neurochemical responses to Mph among ADHD patients. Therefore, further studies are needed to fully characterize the effects of the Val158met polymorphism of the COMT gene on treatment outcomes in patients with ADHD.
Keyphrases
- attention deficit hyperactivity disorder
- copy number
- genome wide
- end stage renal disease
- autism spectrum disorder
- genome wide identification
- working memory
- newly diagnosed
- ejection fraction
- tyrosine kinase
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- case report
- genome wide analysis
- transcription factor