Oxime@Zirconium-Metal-Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning.

Lydia González Javier D Martin-RomeraPurificación Sánchez-SánchezJorge A R Navarro Elisa Barea Carmen R Maldonado Francisco J Carmona

Published in: Inorganic chemistry (2023)

A novel material with dual activity toward organophosphate (OP) poisoning, based on Zr-MOF-808 and neutral oxime RS69N, has been prepared. The hybrid material has a significant drug payload (5.2 ± 0.9 oxime to MOF-808 molar ratio) and shows a sustained oxime release in simulated physiological media, leading to the successful reactivation of OP-inhibited acetylcholinesterase. At the same time, the hybrid system presents an efficient and moderately fast removal rate of a toxic organophosphorus model compound (diisopropylfluorophosphate) from simulated physiological media ( t 1/2 = 183 min; 95% removal rate after 24 h).

Keyphrases

metal organic framework
pet imaging
risk assessment
human health
climate change
adverse drug
pet ct