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Modeling the Chronification Tendency of Liver Infections as Evolutionary Advantage.

Cordula ReischDirk Langemann
Published in: Bulletin of mathematical biology (2019)
Here, we discuss how the tendency of a liver infection to chronify can be seen as an evolutionary advantage for infected individuals. For this purpose, we present a set of reaction-diffusion equations as a mathematical model of viral liver infections, which allows chronic and acute courses of the liver infection. We introduce a cumulative wealth function, and finally, we show that an immune response favoring the chronification is evolutionary advantageous at the same time.
Keyphrases
  • immune response
  • genome wide
  • liver failure
  • sars cov
  • gene expression
  • inflammatory response
  • toll like receptor
  • respiratory failure
  • extracorporeal membrane oxygenation