The natalizumab wearing-off effect: End of natalizumab cycle, recurrence of MS symptoms.
Zoé Léonie Elise van KempenDjoeke DoesburgIris DekkerBirgit I Lissenberg-WitteAnnick de VriesIris A ClaessenAnja Ten BrinkeTheo RispensJoep KillesteinPublished in: Neurology (2019)
The wearing-off effect is a frequently reported phenomenon but is unlikely to reflect a nonoptimal pharmacokinetic/dynamic state. We did not find risk factors predicting the wearing-off effect.