Histologic characterization and risk factors for persistent albuminuria in adolescents in a region of highly prevalent end-stage renal failure of unknown origin.
Dulce M Macias DiazMyriam Del Carmen Corrales AguirreAna Lilian Reza EscaleraMaria Teresa Tiscareño GutiérrezItzel Ovalle RoblesMariana Jocelyn Macías GuzmánAndrea L García DíazMauricio C Gutiérrez PeñaAndrea Natalia Alvarado-NájeraIsrael González DomínguezJuan Carlos Villavicencio-BautistaAngela Azucena Herrera RodríguezRicardo Marín-GarcíaFrancisco Javier Avelar GonzálezAlfredo Chew WongElba Galván GuerraRodolfo Delgadillo CastañedaCarlos Alberto Prado AguilarLeslie P Zúñiga-MacíasArreola Guerra Jose ManuelPublished in: Clinical kidney journal (2022)
The prevalence of persistent albuminuria in adolescents in Aguascalientes is high and histologic compromise is characterized by podocyte injury in the absence of fibrosis. The renal volume of persistent albuminuria patients was decreased, suggesting oligonephronia. Exposure to environmental toxins such as pesticides, even prenatally, may be responsible for this pathological entity. Screening programs in adolescents by determining ACR are necessary in this setting.