Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders.

P AuvinenJ VehviläinenH MarjonenV ModhukurJ SokkaE WallénK RämöL AholaA SalumetsT OtonkoskiH SkottmanM OllikainenR TrokovicH KahilaNina Kaminen-Ahola

Published in: BMC medicine (2022)

Our study shows the effects of early alcohol exposure on human embryonic and extraembryonic cells, introduces candidate genes for alcohol-induced developmental disorders, and reveals potential biomarkers for prenatal alcohol exposure.

Keyphrases

alcohol consumption
high glucose
endothelial cells
diabetic rats
genome wide
induced apoptosis
gene expression
pregnant women
drug induced
dna damage
oxidative stress
dna methylation
cell proliferation
copy number
genome wide identification