Chronic inflammation-induced senescence impairs immunomodulatory properties of synovial fluid mesenchymal stem cells in rheumatoid arthritis.

Hyeon-Jeong LeeWon-Jae LeeSun-Chul HwangYongho ChoeSaetbyul KimEunyeong BokSangyeob LeeSeung-Joon KimHyun-Ok KimSun-A OckHae-Sook NohGyu-Jin RhoSang-Il LeeSung-Lim Lee

Published in: Stem cell research & therapy (2021)

We conclude that a chronic RA inflammatory milieu affects the MSC potential. Therefore, this work addresses the importance of understanding MSC characteristics during disease states prior to their application in patients.

Keyphrases

rheumatoid arthritis
mesenchymal stem cells
end stage renal disease
oxidative stress
ejection fraction
newly diagnosed
disease activity
chronic kidney disease
peritoneal dialysis
prognostic factors
ankylosing spondylitis
endothelial cells
stem cells
umbilical cord
interstitial lung disease
stress induced