L1CAM promotes ovarian cancer stemness and tumor initiation via FGFR1/SRC/STAT3 signaling.

Marco GiordanoAlessandra DecioChiara BattistiniMicol BaronioFabrizio BianchiAlessandra VillaGiovanni BertalotStefano FreddiMichela LupiaMaria Giovanna JodicePaolo UbezioNicoletta ColomboRaffaella GiavazziUgo Cavallaro

Published in: Journal of experimental & clinical cancer research : CR (2021)

Our study implicate L1CAM in the tumorigenic function of OCSC and point to the L1CAM/FGFR1/SRC/STAT3 signaling pathway as a novel driver of OC stemness. We also provide evidence that targeting this pathway can contribute to OC eradication.

Keyphrases

epithelial mesenchymal transition
stem cells
signaling pathway
tyrosine kinase
cell proliferation
pi k akt
helicobacter pylori infection
oxidative stress
drug delivery