Effects of APOE e4-allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe).
Francisca S RodriguezSusanne RöhrAlexander PabstLuca KleineidamAngela FuchsBirgitt WieseDagmar LühmannChristian BrettschneiderSteffen WolfsgruberMichael PentzekHendrik van den BusscheHans-Helmut KönigSiegfried WeyererJochen WerleHorst BickelDagmar WeegWolfgang MaierMartin SchererMichael WagnerSteffi G Riedel-HellerPublished in: International journal of geriatric psychiatry (2020)
Our longitudinal observations suggest that cognitive decline could be slowed by an intellectually enriched lifestyle even in risk gene carriers. Fostering intellectual engagement throughout the life-course could be a key prevention initiative to promote better cognitive health in old age.
Keyphrases
- cognitive decline
- mild cognitive impairment
- primary care
- end stage renal disease
- mental health
- newly diagnosed
- chronic kidney disease
- healthcare
- public health
- prognostic factors
- metabolic syndrome
- cardiovascular disease
- physical activity
- social media
- quality improvement
- patient reported outcomes
- adipose tissue
- cognitive impairment
- type diabetes
- gene expression
- white matter
- health information
- risk assessment
- genome wide identification
- genome wide analysis