An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain.
Junjun NiZhou WuJie MengTakashi SaitoTakaomi C SaidoHong QingHiroshi NakanishiPublished in: Journal of neuroinflammation (2019)
Clock gene disturbance in microglia is involved in the early onset of AD through the induction of chronic neuroinflammation, which may be a new target for preventing or slowing AD.
Keyphrases
- early onset
- early stage
- inflammatory response
- lipopolysaccharide induced
- lps induced
- late onset
- neuropathic pain
- genome wide
- copy number
- traumatic brain injury
- protein protein
- sentinel lymph node
- genome wide identification
- amino acid
- spinal cord injury
- cerebral ischemia
- spinal cord
- binding protein
- radiation therapy
- genome wide analysis
- brain injury