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New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis.

Meng-Yu WuGiou-Teng YiangMing-Feng HouPei-Yi Chu
Published in: International journal of molecular sciences (2017)
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids, smooth muscle cell proliferation, cell apoptosis, necrosis, fibrosis, and local inflammation. Immune and inflammatory responses have significant effects on every phase of atherosclerosis, and increasing evidence shows that immunity plays a more important role in atherosclerosis by tightly regulating its progression. Therefore, understanding the relationship between immune responses and the atherosclerotic microenvironment is extremely important. This article reviews existing knowledge regarding the pathogenesis of immune responses in the atherosclerotic microenvironment, and the immune mechanisms involved in atherosclerosis formation and activation.
Keyphrases
  • immune response
  • cardiovascular disease
  • cell proliferation
  • smooth muscle
  • oxidative stress
  • stem cells
  • healthcare
  • toll like receptor
  • type diabetes
  • cell cycle
  • inflammatory response
  • signaling pathway