Dexamethasone and potassium canrenoate alleviate hyperalgesia by competitively regulating IL-6/JAK2/STAT3 signaling pathway during inflammatory pain in vivo and in vitro.

Jie LiuXiaolan XieKai QinLe XuJuxiang PengXiangyu LiXiongjuan LiZhiheng Liu

Published in: Immunity, inflammation and disease (2022)

There was no additive or negative effect of Dexa and Cane, and they modulate the IL-6/JAK2/STAT3 signaling pathway through competitive binding with IL-6 and relieves hypersensitivity during inflammatory pain.

Keyphrases

signaling pathway
neuropathic pain
chronic pain
pain management
pi k akt
oxidative stress
epithelial mesenchymal transition
induced apoptosis
low dose
spinal cord injury
spinal cord
cell proliferation
transcription factor
dna binding