LA-ICP-MS analysis reveals differences in chemotherapeutic drug distribution in surgically resected pleural mesothelioma.

Anna TiszaThomas KlikovitsMichal BenejSzilvia TorokBeata SzeitzZsuzsanna ValkoMir Alireza HodaBalazs HegedusMaximilian BontaWinfried NischkauerKonrad HoetzeneckerAndreas LimbeckKarin SchelchViktoria LaszloZsolt MegyesfalviBalázs Dome

Published in: British journal of clinical pharmacology (2023)

There are major differences in drug distribution between tumorous and non-tumorous areas of PM specimens. Serum Pt levels significantly correlate with full section- and tumorous areas average Pt levels, elapsed time from the last CHT cycle, and OS. Further studies investigating clinicopathological factors that modulate tissue Pt concentration and distribution are warranted.

Keyphrases

mass spectrometry
ms ms
multiple sclerosis
air pollution
lymph node
particulate matter
adverse drug
risk assessment